Degradation and Reprocessing of Heparan Sulphate in Recycling Glypican (Heparan Sulphate Proteoglycan).
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چکیده
منابع مشابه
Interferon and heparan sulphate.
In 1954, substances that protected cells from viral infection were discovered and named IFN (interferon). This family of cytokines, which were the first to be used in clinical therapy, is classified into type I and II IFNs. Type I mainly consists of IFNalpha and IFNbeta subtypes, which are structurally related and bind to a common receptor. IFNgamma, the sole type II IFN, is structurally unrela...
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A heparan sulphate proteoglycan was purified from adult bovine brain tissues and its structure was characterized. The major heparan sulphate proteoglycan from whole bovine brain had a molecular mass of >200 kDa on denaturing SDS/PAGE and a core protein size of 66 kDa following the removal of glycosaminoglycan chains. Fractionation on DEAE-Sephacel showed that this proteoglycan consisted of thre...
متن کاملIdentification of a new membrane-bound heparan sulphate proteoglycan.
The morphological changes that occur during intestinal development have been extensively described, but the molecular basis of these changes is largely unknown. As a result of our efforts to identify molecules that play a role in intestinal morphogenesis during development, we have previously isolated a cDNA that is developmentally regulated in the intestine. This cDNA, named OCI-5, was recentl...
متن کاملEstradiol induces heparanase-1 expression and heparan sulphate proteoglycan degradation in human endometrium.
BACKGROUND This study seeks to determine whether estrogen is able to regulate the expression of heparanase-1 (HPR1) in human endometrium. METHODS HPR1 expression and heparan sulphate (HS) deposition in the endometrium collected in various menstrual phases were analysed by immunohistochemical and immunofluorescence staining, respectively. HPR1 expression in the endometrial cells unexposed or e...
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HS influences fundamental cellular properties and biochemical processes at the cell surface. In addition to the issues already discussed, it has a profound effect on cell adhesion and migration through its interaction with many extracellular matrix proteins, most notably fibronectin and thrombospondin; it is closely linked to lipid metabolism through its capacity to bind low-density lipoprotein...
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ژورنال
عنوان ژورنال: Trends in Glycoscience and Glycotechnology
سال: 1998
ISSN: 0915-7352,1883-2113
DOI: 10.4052/tigg.10.81